Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differenc

• 作 者: Vitor Sueth-Santiago Debora Decote-Ricardo Alexandre Morrot Celio Geraldo Freire-de-Lima Marco Edilson Freire Lima
• 机 构: Instituto Federal de Educa??o, Ciência e Tecnologia do Rio de Janeiro, Campus S?o Gon?alo,Universida
• 出 处: World Journal of Biological Chemistry
• 发表日期: 2017年01期
• 关键词: parasite tubulin sentence Figure neglected polymerization chemotherapy highlight

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.