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目的:阐明治疗药物监测(TDM)对抗癫痫药(AEDs)合理用药的意义,关注临床科室对TDM的认识程度。方法:建立AEDs的.Access数据库,结合性别与年龄分析我院2001～2006年AEDs的TDM结果。结果:我院AEDs的监测例数逐年上升;各种AEDs在有效浓度范围内的监测例次比例不高,且因年龄与性别存在一定差异。结论:TDM虽然应用日益广泛,但患者个体用药信息缺乏限制了AEDs个体化用药的发展。需医师、药师共同努力,促进AEDs的合理使用。
Objective: To clarify the significance of TDM in the rational use of antiepileptic drugs (AEDs) and to pay attention to the level of understanding of TDM in clinical departments. Methods: The AEDs Access database was set up to analyze the TDM results of AEDs in our hospital from 2001 to 2006 in combination with sex and age. Results: The number of surveillance cases of AEDs in our hospital increased year by year. The percentage of surveillance cases of various AEDs in the effective concentration range was not high, and there was a certain difference due to age and gender. Conclusion: Although the application of TDM is more and more widely used, the lack of individual medication information limits the individualized development of AEDs. Requires physicians, pharmacists work together to promote the rational use of AEDs.