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1 对象与方法 1.1 病例选择 58例患者均为1997年1月～1998年4月的住院病人。按照1995年北京第五次全国传染病寄生虫病学术会议修订的病毒性肝炎诊断标准,诊断为乙肝后肝硬变,活动期。其中男39例,女19例,年龄最大者67岁.最小者35岁。主要临床表现有乏力、纳差、腹胀、尿少及不同程度的腹水等。 1.2 治疗方法 采用江苏如皋生化制药厂提供的由猪肝中提取的RNA冻干粉针剂,剂量60mg/d,加入10％葡萄糖250ml中静脉滴注,总疗程3个月。基础治疗加用肌苷、维生素、利尿剂及中药疏肝健脾、活血化瘀等,不加用其他抗肝纤维化及劝肝脏胶原、蛋白有影响的药物。 1.3 观察指标 治疗前及治疗后第1、2、3个月,分别检查患者血清ALT、TBil、白蛋白、球蛋白、白/球比值及肝纤维化指标PCⅢ、HA。并将治疗后最后一次检查结果与治疗前对比,作统计学分析,以t检验为分析方法。
1 objects and methods 1.1 Case Selection 58 patients were January 1997 ~ April 1998 inpatients. In accordance with the diagnostic criteria for viral hepatitis revised in the Fifth National Conference on Infectious Diseases of Parasitic Diseases in 1995, diagnosis of post-hepatitis B cirrhosis and active stage. There were 39 males and 19 females, the oldest being 67 years old and the youngest being 35 years old. The main clinical manifestations of fatigue, anorexia, abdominal distension, oliguria and varying degrees of ascites. 1.2 Treatment methods Rugao biochemical pharmaceutical factory in Jiangsu RNA extracted from the liver freeze-dried powder, a dose of 60mg / d, added 10% glucose 250ml intravenous infusion, the total course of 3 months. The basis of treatment plus inosine, vitamins, diuretics and Chinese medicine Shuganjianpi, blood circulation, etc., do not add other anti-liver fibrosis and liver collagen, protein-influential drugs. 1.3 Observation Index Before treatment and after treatment 1, 2, 3 months, respectively, check patients serum ALT, TBil, albumin, globulin, white / ball ratio and liver fibrosis indicators PC Ⅲ, HA. And after treatment the last test results compared with before treatment, for statistical analysis, t test for the analysis.