论文部分内容阅读
驱肠虫药左旋咪唑对缺乏细胞免疫的患者具有免疫刺激性能,因而广泛应用于各种疾病。左旋咪唑引起的皮肤坏死性血管炎尚未有报道,作者在一组应用该药的乳癌患者中发现一例,报道如下: 患者,女,59岁。应用左旋咪唑每周3次,150毫克/日,3个月后出现发热和严重皮疹,诊断为皮肤坏死性血管炎。病损活检发现血管壁广泛嗜中性白细胞和嗜酸性白细胞浸润,血管腔阻塞。无其他异常发现,也无原有疾病体征。患者未用其他任何药物。血红蛋白13克%,白细胞总数3000/立方毫米,嗜中性分叶核白细胞30%,嗜酸性白细胞8%,单核细胞10%,淋巴细胞52%。补体和其他免疫学及生化检查均在正常范围。骨髓检查红细胞系和白细胞系均
Levamisole, an anthelmintic drug, has immunostimulatory properties in patients lacking cellular immunity and is therefore widely used in various diseases. Levamisole-induced skin necrotizing vasculitis has not been reported, the authors found in a group of patients with breast cancer patients, reported as follows: patients, female, 59 years old. Levamisole was administered 3 times a week, 150 mg / day, and fever and severe rash occurred 3 months later, diagnosing skin necrotising vasculitis. Biopsy lesions found extensive vascular wall neutrophil and eosinophilic infiltration, vascular occlusion. No other abnormalities found, nor the original signs of disease. Patients do not use any other drugs. Hemoglobin 13%, leukocytes 3000 / mm3, neutrophilic leukocytes 30%, eosinophils 8%, monocytes 10%, and lymphocytes 52%. Complement and other immunological and biochemical tests are in the normal range. Bone marrow examination of erythroid and leucocyte lines are