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目的:探讨间歇性内分泌治疗对中晚期前列腺癌患者的疗效。方法:从2009年3月至2011年5月化州市人民医院收治的中晚期前列腺癌患者中选出90例患者作为研究对象,先进行6~9个月的内分泌治疗,依据疗效评估将对内分泌治疗敏感患者随机分为间歇治疗组与持续治疗组,对两组患者治疗疗效情况进行观察。结果:间歇治疗组患者在治疗过程中其生活评定卡氏功能状态量表(KPS)评分要明显对持续治疗组患者高,差异具有统计学意义(P<0.05),相关副作用包括潮热、乏力、贫血、体质量减轻骨质疏松方面发生率比持续治疗组患者低,差异具有统计学意义(P<0.05),但是两组患者5年生存率及5年内发展成为非激素依赖性前列腺癌比例比较,差异均无统计学意义(P>0.05)。结论:间歇性内分泌治疗对中晚期前列腺癌患者来说是疗效满意、安全可行的,可显著提高患者生活质量,但前提是需要在对肿瘤情况密切监测下进行。
Objective: To investigate the effect of intermittent endocrine therapy on patients with advanced prostate cancer. METHODS: From March 2009 to May 2011, 90 patients with advanced prostate cancer admitted to Huazhou People’s Hospital were enrolled in this study. Endocrine therapy was performed for 6 to 9 months. According to the assessment of efficacy, Endocrine therapy sensitive patients were randomly divided into intermittent treatment group and continuous treatment group, the treatment of two groups of patients were observed. Results: The KPS scores of patients in intermittent treatment group were significantly higher than those in continuous treatment group during treatment (P <0.05). The related side effects included hot flashes, fatigue (P <0.05). However, the 5-year survival rate and the proportion of non-hormone-dependent prostate cancer within 5 years in both groups were significantly higher than those in the continuous treatment group There was no significant difference between the two groups (P> 0.05). CONCLUSIONS: Intermittent endocrine therapy is satisfactory, safe and feasible for patients with advanced prostate cancer, and can significantly improve the quality of life of patients, but the premise is that close monitoring of the tumor needs to be carried out.