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目的:探讨中西医结合治疗类风湿性关节炎(RA)的作用机制。方法:RA患者60例,给予中药、针灸加甲氨喋呤(MTX)治疗,观察治疗前后血清肿瘤坏死因子(TNF-α)值变化并与ESR、CRP进行相关性分析,测定血清超氧化物歧化酶(SOD)含量及血清过氧化脂质(LPO)值的改变。并设正常对照组观察。结果:本法能明显降低TNF-α水平,提高血清SOD含量,并使LPO水平明显下降。结论:中西医结合治疗RA可能通过调节细胞因子水平,提高机体抗氧化能力从而达到治疗目的。
Objective: To explore the mechanism of Integrative Medicine in the treatment of rheumatoid arthritis (RA). Methods: Sixty patients with RA were treated with traditional Chinese medicine and acupuncture plus methotrexate (MTX). The changes of serum tumor necrosis factor (TNF-α) levels before and after treatment were observed and compared with those of ESR and CRP. The levels of serum superoxide (SOD) content and serum lipid peroxide (LPO) value changes. And set the normal control group observation. Results: This method can significantly reduce the level of TNF-α, increase serum SOD, and significantly reduce the level of LPO. Conclusion: The combination of TCM and Western medicine treatment of RA may be through the regulation of cytokine levels, improve the body’s antioxidant capacity so as to achieve the purpose of treatment.