论文部分内容阅读
目的研究不同剂量开环异落叶松树脂酚二葡萄糖苷(SDG)对去卵巢大鼠降血脂及提高机体抗氧化能力的影响。方法 3周龄SD大鼠随机分为6组,每组8只:假手术组、去卵巢组和去卵巢后不同剂量SDG补充组(10 mg/kg SDG组、20 mg/kg SDG组、50 mg/kg SDG组和100 mg/kg SDG组)。d 60末取血测定总胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、超过氧化物岐化酶(SOD)和丙二醛(MDA)含量。结果去卵巢组的SOD、HDL与假手术组比较显著降低(P﹤0.05),而去卵巢组的TG、TC、LDL、MDA与假手术组比较显著升高(P﹤0.05);补充SDG后,不同剂量组的SOD、HDL与去卵巢组比较显著升高(P﹤0.05),而不同剂量组的TG、TC、LDL、MDA与去卵巢组比较显著降低(P﹤0.05)。结论去卵巢后大鼠血清中抗氧化能力下降,血脂代谢紊乱,补充SDG后可以改善这种状况,并且存在剂量反应关系。
Objective To investigate the effects of different dosages of open-chain Larch (EPG) diglucoside (SDG) on the anti-hyperlipidemia and antioxidant capacity in ovariectomized rats. Methods Three-week-old SD rats were randomly divided into 6 groups with 8 rats in each group: sham operation group, ovariectomized group and SDG supplemented group (10 mg / kg SDG group, 20 mg / kg SDG group, 50 mg / kg SDG group and 100 mg / kg SDG group). At the end of d 60, the levels of total cholesterol (CHO), triglyceride (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), superoxide dismutase (SOD) (MDA) content. Results The levels of SOD and HDL in ovariectomized group were significantly lower than those in sham operation group (P <0.05), while the levels of TG, TC, LDL and MDA in ovariectomized group were significantly higher than those in sham operated group (P <0.05) (P <0.05). However, the levels of TG, TC, LDL and MDA in different dose groups were significantly lower than those in ovariectomized groups (P <0.05). Conclusion After ovariectomized, serum anti-oxidant ability and dyslipidemia in serum of SD rats may be improved after SDG administration, and there is dose-response relationship.