EXPRESSION OF MHC-Ⅰ AND MHC-Ⅱ ANTIGENS IN ENDOMYOCARDIAL BIOPSIES FROM PATIENTS WITH VIRAL MYOCARDIT

• 作 者: 李武 余枢 赵华月
• 机 构: Department of Internal Medicine Tongji Hospital Tongji Medical University Wuhan 430030,Department of
• 出 处: Chinese Medical Journal
• 发表日期: 1995年11期
• 关键词: dilated cardiomyopathy autoimmune myocarditis capillary reactivity mononuclear a

In situ expression of major histocompatibility complex (MHC) Ⅰ and Ⅱ antigens were examined in endomyocardial biopsy samples from 35 patients with viral myocarditis (VMC) and dilated cardiomyopathy (DCM). Increased expressions of these 2 antigens were observed on endocardia, capillary endothelia, dentritic and mononuclear cell membranes. The expression of sarcolemma was also found in specimens of VMC and DCM. Thus the abnormal expression of MHC is a new marker of autoimmune reactivity directed against cardiac structures.

In situ expression of major histocompatibility complex (MHC) I and II antigens were examined in endomyocardial biopsy samples from 35 patients with viral myocarditis (VMC) and dilated cardiomyopathy (DCM). Increased expressions of these 2 antigens were observed on endocardia, capillary endothelia, dentritic and mononuclear cell membranes. The expression of sarcolemma was also found in specimens of VMC and DCM. Thus the abnormal expression of MHC is a new marker of autoimmune reactivity directed against cardiac structures.