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目的:探讨六味地黄胶囊和六味地黄汤加味对阿霉素性大鼠肾病综合征的作用。方法:腹腔注射(ip)阿霉素3mg/ (kg·d) ,q 3d×3d诱导大鼠肾病综合征模型,观察高、低剂量六味地黄汤加味及六味地黄胶囊对病鼠肾功能、血脂、血浆蛋白、肾组织病理学和抗氧化作用的影响。结果:以上3种药物均能降低病鼠高值尿素氮(BUN)、肌酐(Cr)水平(P <0 .0 1)及总胆固醇(TC)、甘油三酯(TG)、丙二醛(MDA)含量(P <0 .0 1) ,提高病鼠低下的总蛋白(TP)和白蛋白(A)含量(P <0 .0 1) ,增强超氧化物歧化酶(SOD)活性(P <0 .0 1) ;改善病鼠肾组织病理学的改变(P <0 .0 1) ,但六味地黄胶囊对病鼠肾组织病理学的改变,则未见显著性(P >0 .0 5 )。在上述各观察指标中,各药间的作用强度,差异也未见显著性(P >0 .0 5 )。结论:六味地黄胶囊和六味地黄汤加味均具有对抗阿霉素性大鼠肾病综合征的氮质血症、低蛋白血症和高脂血症作用。
Objective: To investigate the effect of Liuwei Dihuang Capsule and Liuwei Dihuang Decoction on adriamycin-induced nephrotic syndrome in rats. METHODS: Rats with nephrotic syndrome were induced by intraperitoneal injection (ip) of 3 mg/(kg·d) doxorubicin and q 3d×3d to observe the effects of high- and low-dose Liuweidihuang Decoction and Liuwei Dihuang capsule on renal function and blood lipids of the rats. , plasma protein, renal histopathology, and antioxidant effects. RESULTS: The above three drugs all reduced the levels of BUN, creatinine (Cr) (P < 0.01) and total cholesterol (TC), triglycerides (TG), and malondialdehyde in sick rats. MDA content (P < 0.01) increased the total protein (TP) and albumin (A) content of the diseased mice (P < 0.01) and enhanced the activity of superoxide dismutase (SOD) (P <0. 0 1) Improvement of pathological changes in the kidneys of rats (P < 0.01), but there was no significant difference in the histopathological changes of kidneys of rats with Liu Wei Di Huang Capsule (P > 0.05). 5). Among the above observations, there was no significant difference in the strength of action among the drugs (P > 0.05). Conclusion: The effects of Liuwei Dihuang Capsule and Liuwei Dihuang Decoction on azotemia, hypoalbuminemia and hyperlipidemia in rats against adriamycin-induced nephrotic syndrome.