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目的 探讨前列腺增生症合并急性尿潴留对血清前列腺特异性抗原 (PSA)浓度的影响。方法 回顾性分析 2 0 0 2年 10月至 2 0 0 3年 12月 16例 6 1～ 84岁的前列腺增生症合并急性尿潴留患者导尿前和留置尿管引流 1周后的血清PSA浓度 ,同期以需手术的前列腺增生症患者 5 1例术前血清PSA浓度为对照组 ,对比其血清PSA浓度的变化。结果 急性尿潴留组和对照组的血清PSA浓度分别为 19 5± 11 6 μg/L和 3 4± 2 2 μg/L ,两组间差异有非常显著意义 (t=14 2 6 ,P <0 0 0 1) ;16例急性尿潴留组 ,留置尿管引流 1周后血清PSA浓度较导尿前明显下降 (t=8 96 ,P <0 0 0 1)。结论 前列腺增生症合并急性尿潴留时血清PSA浓度明显升高 ,留置尿管引流 1周后PSA浓度可逐渐下降
Objective To investigate the effect of acute urinary retention in patients with benign prostatic hyperplasia (BPH) on the serum PSA level. Methods The clinical data of 16 patients with benign prostatic hyperplasia (6-184 years old) with acute urinary retention between October 2002 and December 2003 were retrospectively analyzed. The serum PSA levels were measured before catheterization and indwelling catheter drainage for 1 week 51 patients with benign prostatic hyperplasia required surgery for the same period the serum PSA concentration as a control group, compared with changes in serum PSA levels. Results The serum PSA levels in the acute urinary retention group and the control group were 19 5 ± 11 6 μg / L and 34 ± 22 μg / L respectively, with significant differences between the two groups (t = 14 2 6, P 0 The serum PSA levels in 16 patients with acute urinary retention after 1-week drainage catheterization were significantly lower than those before catheterization (t = 8 96, P 0 01). Conclusions The concentration of serum PSA in patients with benign prostatic hyperplasia complicated with acute urinary retention is significantly increased. The concentration of PSA can be gradually decreased