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随着干细胞移植技术的迅速发展,人们迫切需要一种能在体外无创性检测移植干细胞在体内的生物学行为、评估干细胞的移植效果、提供移植疗法的最优化信息的活体示踪方法。磁共振因为具有较高的时间、空间分辨率、良好的组织结构对比、无放射线损伤等优势,无疑成为干细胞活体示踪较为理想的工具,为干细胞移植治疗的临床研究提供有力的影像学帮助。干细胞磁共振活体示踪目前主要处于动物试验阶段,研究领域较为广泛,本文主要针对超顺磁性氧化铁颗粒、钆螯合物标记干细胞移植活体磁共振示踪在CNS中的研究进行综述。
With the rapid development of stem cell transplantation, there is an urgent need for an in vivo method of in vivo tracking of the biological behavior of transplanted stem cells in vitro, assessing the effect of stem cell transplantation, and providing optimal information on the transplantation therapy. Due to its advantages such as high time and spatial resolution, good contrast of tissue structure and no radiation damage, MRI will undoubtedly become an ideal tool for in vivo tracing of stem cells and provide powerful imaging help for the clinical research of stem cell transplantation. At present, most of the studies on the field of stem cell magnetic resonance (ROS) tracer are in the experimental stage of animal experiments, and the research fields are quite extensive. This review focuses on the study of MRS tracing of superparamagnetic iron oxide particles and gadolinium chelate labeled stem cell transplantation in the CNS.