Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and

• 作 者: Luis R Lopez Kirk E Guyer Igna
• 机 构: CorgenixMedicalCorporation,DepartmentofChemistry,DepartmentofImmunologyandRheumatology,Collaborative
• 出 处: 世界糖尿病杂志：英文版（电子版）
• 发表日期: 2014年2期
• 关键词: DIABETES Cardiovascular disease PLATELETS THROMBOXANE ASPIRIN DiabetesCardiovasc
• 基金项目: Supported by In part by the Senit Foundation,Scotland(United Kingdom),grant-in-aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology(Japan)

Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease