Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells

• 作 者: Vladimir P Baklaushev Oleg V Durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekat
• 机 构: BiomedicalResearch,DepartmentofNeurosurgery,DepartmentofAnesthesiology,RadiologyandClinicalPhysiolog
• 出 处: 世界干细胞杂志:英文版(电子版)
• 发表日期: 2021年5期
• 关键词: Direct cell reprogramming Neural precursor cells Directly reprogrammed neural pr
• 基金项目: Supported by Russian Science Foundation,No.16-15-10432。

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal mode