论文部分内容阅读
自 Almeida 等于1971年发现乙型肝炎核心抗原(HBcAg)及其抗体(抗 HBc)系统以来,研究证明抗 HBc 的出现是乙肝病毒(HBV)感染的重要标志。测定抗 HBc 能检出 HBsAg、抗 HBs 系统所不能发现的 HBV感染,可进一步提高乙型肝炎的临床诊断水平和筛选助血员的质量,在乙肝流行病学调查、疫苗安全性鉴定和肝癌病因研究等方面也有重要的价值。免疫粘连血凝法(下称 IAHA)检测抗 HBc,其灵敏度显著高于补体结合等方法,但所用 HBcAg 需经区带密度梯度超速离心法提纯精制,以消除
Since Almeida was found equal to hepatitis B core antigen (HBcAg) and its antibody (anti-HBc) system in 1971, studies have shown that the appearance of anti-HBc is an important marker of hepatitis B virus (HBV) infection. Determination of anti-HBc HBsAg can be detected, anti-HBs system can not be found in HBV infection, hepatitis B can further improve the clinical diagnosis and screening of blood-assistants quality, hepatitis B epidemiology, vaccine safety identification and the cause of liver cancer Research and other aspects also have important value. Immunoblastic hemagglutination (hereinafter referred to as IAHA) detection of anti-HBc, its sensitivity was significantly higher than complement fixation and other methods, but the use of HBcAg required by the density gradient ultracentrifugation Purification to eliminate