论文部分内容阅读
目的对384例荧光梅毒螺旋体抗体吸附试验(FTA-ABS)检测结果进行分析,更好地为临床提供梅毒诊断的依据。方法对2012年确诊梅毒并经FTA-ABS检测为阳性的384例患者的血清,同时用梅毒螺旋体明胶颗粒凝集法(TPPA)和酶联免疫吸附试验(ELISA)进行复核检测,并对其中的40例患者进行脑脊液FTA-ABS检测。结果 384例FTA-ABS检测确诊的阳性病例中,梅毒抗体IgG、IgM同时阳性的59例(占15.4%),抗体IgG阳性IgM阴性的325例(占84.6%)。40例脑脊液中抗体IgG阳性的12例,未见抗体IgM阳性。梅毒合并感染HIV的患者有29例(占7.6%),其中RPR滴度>1∶8有21例(72.4%)。单纯梅毒感染的355例(92.4%),其中RPR滴度>1∶8有97例(27.3%)。结论 FTA-ABS试验敏感性和特异性高,值得在临床中推广。
OBJECTIVE: To analyze the results of FTA-ABS test in 384 cases of Treponema pallidum and to provide a basis for the clinical diagnosis of syphilis. Methods Serum samples from 384 patients with confirmed syphilis and positive by FTA-ABS in 2012 were retrospectively detected by TPPA and ELISA, and 40 Cases of patients with cerebrospinal fluid FTA-ABS test. Results Among the 384 positive cases diagnosed by FTA-ABS test, 59 cases (15.4%) were positive for syphilis antibody IgG and IgM at the same time, and 325 cases (84.6%) were negative for IgG antibody. In 40 cases of cerebrospinal fluid antibody IgG positive in 12 cases, no antibody IgM positive. Twenty-nine patients (7.6%) were infected with syphilis and HIV, 21 (72.4%) with RPR titer> 1: 8. There were 355 cases (92.4%) with simple syphilis infection, of which 97 cases (27.3%) had RPR titer> 1: 8. Conclusion The FTA-ABS test has high sensitivity and specificity and is worth popularizing in clinic.