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目的为明确脑血栓患者凝血纤溶系统的功能状态。方法采用ＥＬＩＳＡ法监测３０例脑血栓形成患者血浆纤维蛋白肽Ａ（ＦＰＡ）和Ｄ－二聚体（ＤＤ）在急性期（≤３ｄ）、亚急性期（８～２８ｄ）、慢性期（＞３０ｄ）的动态变化，并与２０例正常人进行比较。结果ＦＰＡ在脑血栓形成后各期均显著高于对照组，亚急性期、慢性期和急性期之间差异均无显著性；ＤＤ在急性期显著高于对照组，亚急性期较急性期进一步升高，慢性期和急性期之间差异无显著性。脑血栓形成急性期ＴＰＡ、ＤＤ与神经功能缺损评分和梗塞灶体积均无相关性。结论脑血栓形成各期凝血功能均增强，亚急性期纤溶系统高度激活，为脑血栓形成早期行抗凝溶栓治疗提供了理论依据
Purpose To clarify the functional status of coagulation and fibrinolytic system in patients with cerebral thrombosis. Methods Serum levels of fibrinolipid A (FPA) and D-dimer (DD) in 30 patients with cerebral thrombosis were measured by ELISA in the acute phase (≤3d), subacute phase (8 ~ 28d), chronic phase ) Dynamic changes, and compared with 20 normal subjects. Results FPA was significantly higher in all stages of cerebral thrombosis than in control group, there was no significant difference between subacute, chronic and acute phases; DD was significantly higher in acute phase than in control group; subacute phase was further than acute phase There was no significant difference between elevated and chronic phase and acute phase. There was no correlation between TPA, DD and neurological deficit scores and infarct volume in the acute phase of cerebral thrombosis. Conclusions The clotting function in all stages of cerebral thrombosis is enhanced. The subacute fibrinolytic system is highly activated, which provides a theoretical basis for anticoagulant thrombolytic therapy in the early stage of cerebral thrombosis