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目的观察阴道的细菌感染对早产发生率的影响及其治疗对策。方法选择孕期在28-36周的孕妇216例,其中诊断为阴道的细菌感染者145例。随机分为治疗组(A)n=73例采用罗红霉素0.15gBid×7天,并加用灭滴灵0.2gTid×7天;安慰组(B)n=72例,采用VitB110mgTid×7天;另选无细菌感染71例作为对照组(C)。追踪观察孕妇发生早产的病例数。结果A组73例,发生早产15例,发生率为20.5%;B组72例,发生早产30例,发生率42.2%;C组71例,发生早产4例,发生率5.6%。经统计学检验A组与B组对比,P<0.05;B组与C组对比,P<0.01。检出阴道细菌为淋茵12例,早产发生8例,占66.6%,加德纳菌37例,早产发生18例,占48.6%,嗜血杆菌48例,早产发生21例,占43.7%,霉菌77例,早产发生5例,占6.4%等。结论孕妇合并阴道细菌感染,发生早产率高于无阴道细菌感染者,经过治疗可显著降低其发生率。
Objective To observe the influence of vaginal bacterial infection on the incidence of preterm birth and its treatment. Methods Select pregnant women in 28-36 weeks of pregnancy in 216 cases, of which 145 were diagnosed as vaginal bacterial infection. Randomly divided into treatment group (A) n = 73 cases with roxithromycin 0.15gBid × 7 days, and add metronidazole 0.2gTid × 7 days; placebo group (B) n = 72 cases with VitB110mgTid × 7 days 71 cases without bacterial infection were selected as control group (C). Tracing the number of premature pregnancies observed. Results A group of 73 cases, premature birth in 15 cases, the incidence was 20.5%; B group of 72 cases, premature birth occurred in 30 cases, the incidence of 42.2%; C group 71 cases, premature birth in 4 cases, the incidence rate of 5.6%. Statistical analysis A group and B group, P <0.05; B group and C group, P <0.01. There were 12 cases of vaginal bacteria, 8 cases of premature birth, accounting for 66.6%, 37 cases of Gardnerella, 18 cases of premature delivery, accounting for 48.6%, 48 cases of Haemophilus, 21 cases of preterm delivery, accounting for 43.7% 77 cases of mold, premature birth occurred in 5 cases, accounting for 6.4%. Conclusion Pregnant women with vaginal bacterial infection, premature birth rate was higher than those without vaginal bacterial infection, after treatment can significantly reduce the incidence.