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一、临床资料:经确诊为原发性甲亢的116例中,家族性甲亢17例。男5例,女12例:年龄:6～58岁(上代<父母辈30～58岁>,下代<子女辈6～28岁>),其中子女辈16岁以下7例;母女关系8例,母子关系7例,父子关系2例。症状与体征:全部病例均有高代谢症群,神经兴奋,甲状腺肿大,眼征阳性,手抖等临床表现。实验室检查:基础代谢率均大于+20％,甲吸~(131)I 3h和24h均高于40％和50％;TT_3、TT_4分别大于3.54(正常值1.08～3.54nmol/L)和166.7(正常值73.53～163.83nmol/L)nmol/L。二、讨论:甲亢被认为是自体免疫性疾病,与糖尿病一样,具有一定的家族倾向,文献报告与组织相容抗原有密切关系。国内有
First, the clinical data: 116 cases of primary hyperthyroidism was diagnosed, 17 cases of familial hyperthyroidism. There were 5 males and 12 females, aged from 6 to 58 years old (30 to 58 years old in the previous generation and 6 to 28 years old in the next generation), with 7 children under the age of 16 from their sons and daughters; 8 Cases, mother-child relationship in 7 cases, father-son relationship in 2 cases. Symptoms and signs: All cases have high metabolic group, nervous excitement, goiter, eye sign positive, shaking and other clinical manifestations. Laboratory tests showed that the basal metabolic rate was higher than + 20%, the A to 131I levels were higher than 40% and 50% at 3 and 24 hours respectively, and TT_3 and TT_4 were higher than 3.54 and 1.06 ~ 3.54 nmol / L, respectively (Normal 73.53 ~ 163.83nmol / L) nmol / L. Second, the discussion: Hyperthyroidism is considered an autoimmune disease, and diabetes, with a certain family tendency, the literature reports and tissue-compatible antigen are closely related. There are domestic