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(C3H×101)F_1和(SEC×C57BL)F_1两杂系雄鼠受X线照射后,胚胎死亡发生率明显不同,两系雄鼠减数分裂细胞受照后染色体易位频率也存在差异。Generoso等曾研究两杂系精原干细胞遗传物质损伤导致的先天缺陷是否也存在着相似的差异,结果表明,在两杂系中,不仅相互易位率与先天畸形率相关,而且前者比后者有较高的畸变率。近来研究确定:小鼠生殖细胞受电离辐射后,其子一代的某些先天畸形和生长迟缓率均增加。本研究表明,X线照射精原干细胞后的先天畸形发生率与易位相关,而且受照的雄鼠种系也明显影响先天畸形的比率。
(C3H × 101) F_1 and (SEC × C57BL) F_1 two hybrid mice were significantly different in the incidence of X-ray irradiation. There was also a difference in the frequency of chromosome translocations after irradiation between meiosis cells of two males. Generoso et al. Studied whether there were similarities in the birth defects caused by the genetic material damage of the spermatogonial stem cells. The results showed that not only the reciprocal translocation rate was related to the rate of congenital malformations, but also the former was higher than the latter A higher distortion rate. Recent studies have determined that: after germ cell irradiation by ionizing radiation in mice, some of its children have congenital malformations and growth retardation rates increased. This study shows that the incidence of congenital malformations after X-ray irradiation of spermatogonial stem cells is related to translocation, and the irradiated male germline also significantly affects the rate of congenital malformations.