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本文报告由偷食大隆(Brodifacoum)引起的3例人为紫癜病病人的维生素K(以下简称VK)代谢研究。病人由于缺乏依赖VK的凝血蛋白,难以用常规剂量的VK_1医治;需要用鲜冻血浆控制出血,再给予大剂量VK_1。代谢试验证明,由于存在VK对抗剂而阻断了VK利用,但病人不承认吃过抗凝血剂;杀鼠灵试验阴性。因此研究者认为,病人都是由于偷食大隆而得人为紫癜病,大隆是一种作用时间长的VK对抗性强力灭鼠剂。此种凝血病用大剂量VK_1长期
This article reports on vitamin K (hereinafter referred to as VK) metabolic studies in 3 patients with purpura caused by Brodifacoum. Due to a lack of VK-dependent coagulation proteins, patients are difficult to treat with conventional doses of VK-1; hemorrhages are controlled with fresh-frozen plasma and given large doses of VK_1. Metabolic tests have shown that VK use is blocked by the presence of VK antagonists, but the patient does not admit to having eaten anticoagulants; the warfarin test is negative. Therefore, researchers believe that patients are due to steal Dalong artificially purpura, Dalong is a long-acting VK antagonistic rodenticides. This coagulopathy with large doses of VK_1 long-term