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【目的】探讨瑞舒伐他汀联合厄贝沙坦改善颈动脉粥样硬化患者颈动脉血流的疗效。【方法】选择2013年1月至2014年1月本院收治的经颈动脉彩超检查确诊患有颈动脉粥样斑块的60例患者,将其随机分为 A 组和 B 组,每组30例,A 组给予瑞舒伐他汀(每日10 mg)+厄贝沙坦(每日150 mg)治疗,口服12个月,B 组给予瑞舒伐他汀,每日10 mg,口服12个月,观察治疗前、治疗后两组患者血清血脂水平、颈动脉状态、颈动脉血流速度的变化。【结果】60例患者经治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平较治疗前明显下降(P <0.05)。A 组治疗后颈动脉血流情况较治疗前有明显改善,差异具有统计学意义(P <0.05),且明显优于 B 组,差异具有统计学意义(P 0.05)。【结论】瑞舒伐他汀联合或不联合厄贝沙坦均能够降低高脂血症颈动脉粥样硬化患者血清 TC 、TG、LDL-C 水平；但联合应用可以明显改善患者颈动脉血流情况。“,”Objective]To investigate the efficacy of rosuvastatin combined with irbesartan on the improvement of carotid artery flow in patients with carotid artery atherosclerosis.[Methods]Sixty outpatients in our hospital from 2013 January to January,2014 who were confirmed of carotid atherosclerotic plaque by ultrasonography were randomly divided into two groups(Group A and Group B ),30 patients in each group.Patients in Group A were given rosuvastatin (10mg/day,Oral)and irbesartan(1 50mg/day,Oral)for 12 months while Group B was given rosuvastatin (1 50mg/day,Oral )only in the same period.The changes of serum lipid levels,carotid artery and ca-rotid blood flow velocity were examined before and after treatment.[Results]Of 60 patients after treatment,the levels serum total cholesterol (TC),Triacylglycerol(TG),low density lipoprotein cholesterol (LDL-C)were sig-nificantly lower than those before treatment (P <0.05).After the treatment,the carotid blood flow of Group A was improved obviously compared with those before treatment,and the difference was statistically significant (P<0.05),which was better than that of Group B,the difference is statistically significant (P 0.05).[Con-clusion]Rosuvastatin combined or not combined with irbesartan can reduce TC,TG,LDL-C in carotid atheroscle-rosis patients with hyperlipidemia,but the combination can effectively improve the carotid artery flow.