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目的 确认消灭脊髓灰质炎 (脊灰 )免疫策略的重要性。方法 对易感人群不同免疫状况 ,高危人群、环境 (水 )中脊灰病毒动态和急性驰缓性麻痹 (AFP)病人监测。结果 幼儿首次脊灰疫苗强化免疫后 ～ 型中和抗体 GMRT分别为 32 2 .5 2、 198.6 6、 176 .48,与全程基础免疫后的 88.36、 92 .82、 86 .78相比较 ,有非常显著差异 (t=3.0 3,P<0 .0 1)。 1994年～ 1998年对高危人群、环境 (水 )和 AFP病人监测 ,所分离到PV经 RT- PCR基因分析和温度敏感试验均为疫苗相关株。结论 消灭脊灰免疫策略的实施 ,能阻断 PV野毒株循环。
Purpose To confirm the importance of eliminating poliomyelitis (polio) immunization strategies. Methods Surveillance of poliovirus dynamics and acute flirtation paralysis (AFP) in different immunocompetent, high-risk, and environmental (water) susceptible populations. Results The GMRT of type-I neutralizing antibody after the first immunization of young children with poliovirus was 32.2.52, 198.66 and 176.48, respectively, compared with 88.36, 92.82 and 86.78 after basic immunization Significant difference (t = 3.03, P <0.01). From 1994 to 1998, high-risk population, environmental (water) and AFP patients were monitored. The isolated PVs were all vaccine-related strains analyzed by RT-PCR and temperature-sensitive tests. Conclusion The implementation of poliovirus eradication strategy can block the cycling of PV wild-type virus.