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目的 研究C -erbB - 2癌基因在乳腺癌中的表达。方法 采用S -P免疫组化法对 88例乳腺癌进行C-erbB - 2癌基因检测。结果 C -erbB - 2癌基因阳性表达在浸润性导管癌中最高 ;淋巴结转移组高于未出现淋巴结转移组 ;经统计学处理有差异 (P <0 0 5)。与ER(+)PR(+)及病人年龄、月经、肿瘤大小无关。结论 C -erbB - 2癌基因过度表达对乳腺癌预后及治疗方案选择起重要作用
Objective To study the expression of C-erbB-2 oncogene in breast cancer. Methods 88 cases of breast cancer were examined for C-erbB-2 oncogene by S-P immunohistochemistry. Results The positive expression of C-erbB-2 oncogene was the highest in invasive ductal carcinomas. The lymph node metastasis group was higher than that in no lymph node metastasis group. The difference was statistically significant (P <0.05). And ER (+) PR (+) and patient age, menstruation, tumor size has nothing to do. Conclusion Overexpression of C-erbB-2 oncogene plays an important role in prognosis and treatment options of breast cancer