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为探讨低剂量钷－ １４７（１４７ Ｐｍ） 内污染对红细胞系统遗传突变的影响，应用骨髓和血液正常染红细胞微核检测，观察了低剂量１４７ Ｐｍ 内污染小鼠能否改变相继高剂量１４７ Ｐｍ 内污染引起的红细胞染色体的损伤效应。结果显示，１８５ｋ Ｂｑ／ｇ 体重的单纯高剂量１４７ Ｐｍ 内污染可引起骨髓和血液正常染红细胞微核细胞率明显增多，与正常对照组比较有非常显著的统计学差异（ Ｐ ＜ ００１） 。然而，预先应用０３７ ，３７ 和３７ Ｂｑ／ｇ 体重的１４７ Ｐｍ 内污染预处理动物，３ 天后相继给予１８５ｋ Ｂｑ／ｇ 体重的高剂量１４７ Ｐｍ 内污染机体，骨髓和血液正常染红细胞微核细胞率明显减少，与单纯高剂量１４７ Ｐｍ 内污染实验组相比有显著或非常显著的统计学差异（ Ｐ ＜ ００５ 或 Ｐ ＜ ００１） ；并且与正常对照组相比已无显著性差异（ Ｐ ＞ ００５） 。结果表明，低剂量１４７ Ｐｍ 内污染预处理动物，可较长时间诱导红细胞系统的遗传适应性反应，使红细胞系统对相继高剂量１４７ Ｐｍ 内污染引起的染色体损伤有了明显的抵抗力。
In order to investigate the effect of low dose 钷-147 (147 Pm) contamination on erythrocyte genetic mutation, the detection of micronuclei in normal red blood cells by bone marrow and blood samples was used to determine whether high dose 147 Pm Damage effect of erythrocyte chromosome caused by internal pollution. The results showed that the simple high-dose 147 Pm contamination at a dose of 18.5k Bq / g could significantly increase the rate of micronucleated erythrocytes in bone marrow and blood, which was significantly different from the normal control group (P <0 01). However, animals pre-contaminated with 147 Pm of 0 37, 3 7, and 37 Bq / g body weight were pretreated with high-dose 147 Pm of 18 5k Bq / g body weight three days later, with normal bone marrow and blood The rate of micronucleated erythrocytes was significantly decreased, which was significantly or very significantly different from that of the high-dose 147 Pm contaminated experimental group (P <005 or P <001). Compared with the normal control group No significant difference than before (P> 0 05). The results showed that pretreatment of animals with low dose of 147 Pm could induce genetic adaptive reaction of erythrocyte system for a long time and make the erythrocyte system have obvious resistance to chromosome damage caused by successive high dose 147 Pm pollution.