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目的观察儿童清肺口服液治疗小儿呼吸道合胞病毒肺炎的效果。方法选择2011年1月—2013年10月收治的呼吸道合胞病毒肺炎患儿88例,随机分为对照组和治疗组各44例,入院后患儿均给予吸氧、抗病毒、吸痰等对症治疗。对照组给予更昔洛韦5 mg/kg加入100 ml生理盐水静脉滴注,2次/d;治疗组在对照组基础上给予儿童清肺口服液,<12个月10 ml/次,12~36个月20 ml/次,3次/d。两组均治疗14 d评价疗效、症状体征改善时间及住院时间。计量资料采用t检验,计数资料采用x~2检验,P<0.05为差异有统计学意义。结果总有效率对照组70.45%,治疗组97.73%,比较差异有统计学意义(P<0.05)。治疗组发热、咳嗽、啰音消失时间及住院时间[(2.3±1.0)、(4.3±1.0)、(3.5±1.7)、(4.6±2.1)d]均短于对照组[(6.5±2.0)、(7.2±1.5)、(6.7±2.4)、(7.0±2.3)d],两组比较差异均有统计学意义(均P<0.05)。结论儿童清肺口服液治疗小儿呼吸道合胞病毒肺炎可迅速改善患儿症状体征、提高临床疗效、缩短住院时间,值得临床应用。
Objective To observe the effect of Qingfei oral liquid on children with respiratory syncytial virus pneumonia. Methods Eighty-eight children with respiratory syncytial virus pneumonia admitted from January 2011 to October 2013 were randomly divided into control group and treatment group, 44 cases in each group. All patients were given oxygen, antivirus and sputum aspiration after admission Symptomatic treatment. The control group was given ganciclovir 5 mg / kg by adding 100 ml normal saline intravenously, 2 times / d; the treatment group was given the Qingfei oral liquid on the basis of the control group, <12 months 10 ml / 36 months 20 ml / time, 3 times / d. Both groups were treated for 14 days to evaluate the curative effect, the improvement of symptoms and signs and hospital stay. Measurement data using t test, count data using x ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 70.45% in the control group and 97.73% in the treatment group, with significant difference (P <0.05). The duration of fever, cough, rales and hospital stay in the treatment group were shorter than those in the control group [(2.3 ± 1.0), (4.3 ± 1.0), (3.5 ± 1.7), (4.6 ± 2.1) d] , (7.2 ± 1.5), (6.7 ± 2.4), (7.0 ± 2.3) d respectively. There was significant difference between the two groups (all P <0.05). Conclusion Children Qingfei oral solution for children with respiratory syncytial virus pneumonia can rapidly improve children’s symptoms and signs, improve clinical efficacy and shorten the hospital stay, is worth clinical application.