论文部分内容阅读
目的 探讨老年急性胰腺炎 (AP)患者血清一氧化氮 (NO)和肿瘤坏死因子α(TNF α)的变化及临床意义。方法 对 32例老年AP患者及 2 0例健康老年人血清中NO和TNF α水平进行检测。结果 老年AP患者血清中NO浓度明显低于正常对照组 ,且随病情加重降低更为明显 (P <0 0 1 ) ;而血清TNF α浓度明显高于正常对照组 ,且随病情加重升高更为明显 (P <0 0 1 ) ,NO和TNF α呈显著负相关 (P <0 0 5)。结论 NO及TNF α是参与老年AP发生发展的重要因素之一 ,检测其变化有助于病情严重程度的判断
Objective To investigate the changes of serum nitric oxide (NO) and tumor necrosis factor α (TNF α) in elderly patients with acute pancreatitis (AP) and its clinical significance. Methods Serum levels of NO and TNFα were measured in 32 elderly AP patients and 20 healthy elderly patients. Results The concentration of NO in elderly patients with AP was significantly lower than that in the normal control group (P <0.01), while the level of serum TNFα was significantly higher than that in the normal control group (P <0.01), there was a significant negative correlation between NO and TNFα (P <0 05). Conclusion NO and TNFα are one of the important factors involved in the occurrence and development of senile AP. Detecting the changes may contribute to the judgment of the severity of the disease