论文部分内容阅读
目的:观察瑞舒伐他汀对糖尿病大鼠心肌功能和NT-pro-BNP的影响。方法:利用高糖高脂饲料喂养2个月和链脲佐菌素制备Wistar大鼠糖尿病模型,造模成功后继续原饲料喂养并随机分为对照组和瑞舒伐他汀组。对照组每日予生理盐水灌胃,瑞舒伐他汀组每日予瑞舒伐他汀(20mg/kg)灌胃,持续2个月。观察心脏超声指标左室舒张末期内径(LVEDD)、左室后壁厚度(LWPWT)和左室射血分数(EF)的变化;检测两组大鼠实验末血糖情况,血脂指标甘油三酯(TG)、总胆固醇(TC)和心功能指标N末端脑钠肽前体(NT-pro-BNP);计算心脏重量/体重比。结果:瑞舒伐他汀组大鼠实验末的LVEDD和LWPWT指标低于对照组,EF指标高于对照组差异有统计学意义;实验末两组大鼠空腹血糖相比无明显差异;TG、TC和NT-pro-BNP水平明显低于对照组,瑞舒伐他汀组大鼠实验末心脏重量/体重比显著低于对照组。结论:瑞舒伐他汀能改善脂代谢紊乱,降低NT-pro-BNP水平,减轻糖尿病大鼠心肌功能障碍和损伤。
Objective: To observe the effect of rosuvastatin on myocardial function and NT-pro-BNP in diabetic rats. Methods: Wistar rats were fed with high-sucrose and high-fat diet for 2 months and streptozotocin. Diabetic rats were fed with diets and then randomly divided into control group and rosuvastatin group. The control group was given normal saline daily, rosuvastatin group daily rosuvastatin (20mg / kg) intragastrically for 2 months. The changes of left ventricular end-diastolic diameter (LVEDD), left ventricular posterior wall thickness (LWPWT) and left ventricular ejection fraction (EF) were observed. The blood glucose, triglyceride ), Total cholesterol (TC) and cardiac function index N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were calculated. Cardiac weight to body weight ratio was calculated. Results: The LVEDD and LWPWT indexes in rosuvastatin group at the end of the experiment were lower than those in the control group, while the EF index was higher than the control group. There was no significant difference in the fasting blood glucose between the two groups at the end of the experiment. TG, TC And NT-pro-BNP levels were significantly lower than the control group, rosuvastatin group rats at the end of the experimental heart weight / body weight ratio was significantly lower than the control group. Conclusion: Rosuvastatin can improve the disturbance of lipid metabolism, reduce the level of NT-pro-BNP and alleviate myocardial dysfunction and injury in diabetic rats.