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目的:研究不同子宫手术方案对生育期妇女卵巢功能的影响。方法:随机选取自2014年1月至2015年4月于我院进行手术治疗的200例生育期妇女作为研究对象。针对所有患者在术前1d及术后6个月分别进行静脉采血5 m L,比较患者手术前后促卵泡激素(FSH)及雌二醇(E2)水平,不同年龄与手术方案患者手术前后血清抗苗勒氏管激素(AMH)的水平。结果:术后患者的FSH及E2水平与术前比较,差异无统计学意义(P>0.05)。>40岁者手术后的血清AMH水平显著低于术前,差异有统计学意义(P<0.05)。在手术方式中,子宫切除术(子宫全切及广泛性子宫切除)后患者血清AMH显著低于术前的水平,差异有统计学意义(P<0.05)。在手术途径中,腹腔镜辅助子宫切除术后患者血清AMH显著低于术前的水平,差异有统计学意义(P<0.05)。结论:≥40岁患者在接受子宫手术时可能会影响其卵巢储备功能,而子宫全切、广泛性子宫切除以及腹腔镜辅助子宫切除术对患者术后卵巢功能影响更大。
Objective: To study the effect of different uterine surgery programs on the ovarian function in women of reproductive age. METHODS: A total of 200 women of reproductive age who underwent surgical treatment in our hospital from January 2014 to April 2015 were randomly selected as the study subjects. For all patients, 5 ml of venous blood was collected at 1 day before operation and 6 months after operation respectively. The levels of FSH and E2 before and after surgery were compared between the two groups. Miao Le’s tube hormone (AMH) levels. Results: The postoperative patients with FSH and E2 levels compared with preoperative, the difference was not statistically significant (P> 0.05). Serum AMH levels were significantly lower in patients> 40 years old than those before operation, the difference was statistically significant (P <0.05). In the operation mode, the serum AMH of patients after hysterectomy (hysterectomy and extensive hysterectomy) was significantly lower than preoperative levels, the difference was statistically significant (P <0.05). In the surgical approach, serum AMH in patients with laparoscopic-assisted hysterectomy was significantly lower than preoperative levels, the difference was statistically significant (P <0.05). CONCLUSIONS: Patients ≥40 years of age may have an influence on ovarian reserve when undergoing uterine surgery, while total hysterectomy, extensive hysterectomy, and laparoscopic assisted hysterectomy have a greater impact on postoperative ovarian function.