L-Norvaline,a new therapeutic agent against Alzheimer’s disease

• 作 者: Baruh Polis Kolluru D.Srikanth
• 机 构: DrugDiscoveryLaboratory,LaboratoryofCellMigrationandInvasion,LaboratoryofCancerPersonalizedMedicinea
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2019年9期
• 关键词: DEMENTIA ARGINASE inhibition ARGININE urea cycle MICROGLIOSIS NEUROINFLAMMATION
• 基金项目: Marie Curie CIG Grant 322113,Leir Foundation Grant,Ginzburg Family Foundation Grant,Katz Foundation Grant(all to AOS).

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease(AD).Upregulation of arginase was shown to contribute to neurodegeneration.Regulation of arginase activity appears to be a promising approach for interfer