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目的观察瓜蒌薤白颗粒剂防治痰湿闭阻型冠状动脉软斑块PCI术后再狭窄的临床疗效。方法将100例痰湿闭阻型冠状动脉软斑块PCI术后患者随机分为治疗组与对照组,每组50例。对照组予常规西药治疗,治疗组在常规西药的基础上加服瓜蒌薤白颗粒剂。两组疗程均为1年,观察冠状动脉PCI术后再狭窄情况,比较血脂代谢相关指标(TC、TG、LDL-C、HDL-C)及中医证候积分的变化情况。结果 (1)试验期间,治疗组脱落5例、对照组脱落5例,最终完成试验者90例。(2)治疗组、对照组冠状动脉PCI术后再狭窄率分别为2.22%、20.00%;组间冠状动脉PCI术后再狭窄率比较,差异有统计学意义,治疗组明显低于对照组(P<0.05)。(3)组间治疗后比较,TC、TG、LDL-C、HDL-C水平差异有统计学意义,治疗组TC、TG、LDL-C水平明显低于对照组,而治疗组HDL-C水平明显高于对照组(P<0.05)。(4)组间治疗后比较,治疗组中医证候积分明显较对照组更低(P<0.05)。结论瓜蒌薤白颗粒联合常规西药,可明显降低痰湿闭阻型冠状动脉软斑块PCI术后再狭窄率,降低血脂水平,改善临床症状。
Objective To observe the curative effect of guailezhibai granule in preventing and treating restenosis of phlegm-dampness-obstructive coronary artery soft plaque after PCI. Methods 100 patients with phlegm-dampness-obstructive coronary artery soft plaque after PCI were randomly divided into treatment group and control group, 50 cases in each group. The control group was treated with conventional western medicine, and the treatment group was given guacuona granule on the basis of conventional western medicine. The course of treatment was 1 year in each group. The restenosis after coronary artery PCI was observed. The changes of lipid metabolism index (TC, TG, LDL-C, HDL-C) and TCM syndrome scores were compared. Results (1) During the experiment, the treated group shed 5 cases, the control group shed 5 cases and the final completed 90 cases. (2) The restenosis rate of coronary artery after PCI in treatment group and control group were 2.22% and 20.00%, respectively. There was significant difference in the rate of restenosis between PCI group and control group P <0.05). (3) The levels of TC, TG, LDL-C and HDL-C in the two groups after treatment were significantly different, and the levels of TC, TG and LDL-C in the treatment group were significantly lower than those in the control group Significantly higher than the control group (P <0.05). (4) After treatment, the scores of TCM syndromes in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion The combination of Guizhu Xuan Bai granule and conventional western medicine can significantly reduce the rate of restenosis, decrease the level of lipids and improve the clinical symptoms of phlegm-dampness-obstructive coronary soft plaque after PCI.