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目的研究粒细胞淋巴细胞比值(NLR)与胃癌临床病理特征、血清IL-6水平及预后的的关系。方法 2011年3月—2012年3月接受手术的胃癌患者,检测患者术前血常规,血清IL-6,计算NLR,记录患者的临床病理特征,随访患者。分析NLR与胃癌临床病理特征、LI-6的关系,多因素分析术后胃癌患者的生存的预后因素。结果 119名接受根治术的胃腺癌患者,TNMⅠ、Ⅱ、Ⅲ、Ⅳ期分别为17(14.3%)、54(45.4%)、45(37.8%)、3(2.5%)人,IL-6升高伴随NLR增加,差异有统计学意义(P<0.05),NLR与TNM分期有关(P<0.05),多因素分析示,高NLR、非R0切除、TNM分期增加为DFS、OS的预后不良因素(P<0.05)。结论 NLR可能与血清IL-6水平有关,高NLR提示胃癌患者预后不良,可作为预后的预测因子。
Objective To investigate the relationship between granulocyte lymphocyte ratio (NLR) and clinicopathological features, serum IL-6 level and prognosis in gastric cancer. Methods From March 2011 to March 2012, gastric cancer patients undergoing surgery were enrolled in the study. Preoperative blood routine and serum IL-6 levels were measured and NLR was calculated. The patients’ clinical and pathological features were recorded and followed up. To analyze the clinicopathological features of NLR and gastric cancer and the relationship between LI-6 and prognosis of patients with gastric cancer after multi-factor analysis. Results In 119 patients with gastric adenocarcinoma who underwent radical operation, the TNMⅠ, Ⅱ, Ⅲ and Ⅳ were 17 (14.3%), 54 (45.4%), 45 (37.8%) and 3 (2.5% (P <0.05). NLR was correlated with TNM staging (P <0.05). Multivariate analysis showed that high NLR, non-R0 resection and TNM staging increased to DFS and poor prognosis of OS (P <0.05). Conclusion NLR may be related to the level of serum IL-6. High NLR suggests poor prognosis in patients with gastric cancer and can be used as a predictor of prognosis.