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目的:观察柏叶散联合生长抑素辅助治疗上消化道出血的临床疗效。方法:将88例上消化道出血患者随机分为对照组和研究组各44例。对照组予常规治疗,研究组在对照组基础上予柏叶散联合生长抑素治疗。观察2组患者的血流动力学(心率、血氧饱和度、收缩压)变化、不同时间段(第2h、6h、12h、24h)仍出血患者的总例数及临床疗效。结果:研究组总有效率为100%,对照组总有效率90.9%,2组比较,差异有统计学意义(P<0.05)。研究组心率低于对照组,收缩压高于对照组,差异均有统计学意义(P<0.05);2组血氧饱和度比较,差异无统计学意义(P>0.05)。研究组在第2h、6h、12 h、24h的出血总例数均低于对照组,差异均有统计学意义(P<0.05)。结论:柏叶散联合生长抑素辅助治疗上消化道出血,有助于快速止血,有效改善血流动力学,提高临床疗效。
Objective: To observe the clinical efficacy of the combination of Bo Ye San combined with somatostatin in the treatment of upper gastrointestinal bleeding. Methods: 88 cases of upper gastrointestinal bleeding were randomly divided into control group and study group, 44 cases each. The control group was given routine treatment, and the study group was treated with the combination of Berberis powder and somatostatin on the basis of the control group. The changes of hemodynamics (heart rate, blood oxygen saturation, systolic blood pressure) in two groups were observed. The total number of patients with hemorrhage and the clinical curative effect in different time periods (2h, 6h, 12h, 24h) Results: The total effective rate was 100% in the study group and 90.9% in the control group. There was significant difference between the two groups (P <0.05). The heart rate of the study group was lower than that of the control group, and the systolic blood pressure was higher than that of the control group (P <0.05). There was no significant difference in the oxygen saturation between the two groups (P> 0.05). The total number of bleeding in the study group at 2h, 6h, 12h, 24h were lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Bo Ye San combined with somatostatin adjuvant treatment of upper gastrointestinal bleeding, help to quickly stop bleeding, effectively improve hemodynamics and improve clinical efficacy.