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目的:观察以长春瑞滨(Vinorelbine,VNB)为主的联合化疗治疗非小细胞肺癌(NSCLC)和乳腺癌(BC)的疗效。方法:共收治30例恶性肿瘤,其中NSCLC18例,用VP方案,BC12例,用VD方案。初治16例,复治14例。结果:完全缓解(CR)1例,部分缓解(PR)13例,无变化(NC)12例,进展(PD)4例,总有效率为46.7％。中位缓解期6个月,中位生存期9个月,初治有效率为68.8％,复治有效率为21.4％。主要副作用为消化道反应及骨髓抑制。结论:含VNB的联合化疗方案对VSCLC及BC疗效较好,毒副反应可以耐受。
Objective: To observe the efficacy of combined chemotherapy with Vinorelbine (VNB) in the treatment of non-small cell lung cancer (NSCLC) and breast cancer (BC). Methods: A total of 30 cases of malignant tumors were treated. Among them, 18 cases of NSCLC were treated with VP regimen, 12 cases were BC, and VD regimen was used. Initial treatment in 16 cases, retreatment in 14 cases. Results: There were 1 case of complete remission (CR), 13 cases of partial remission (PR), 12 cases of no change (NC), and 4 cases of progression (PD). The total effective rate was 46.7%. The median remission period was 6 months, and the median survival period was 9 months. The initial treatment effective rate was 68.8%, and the retreatment effective rate was 21.4%. The main side effects are gastrointestinal reactions and myelosuppression. Conclusion: The combined chemotherapy regimen with VNB has good curative effect on VSCLC and BC, and toxic and side effects can be tolerated.