Preparation,Rheological Properties and Primary Cytocompatibility of TPU/PLA Blends as Biomedical Mat

• 作 者: 洪华 YANG Lili YUAN Yuan QU Xue CHEN Fangping 魏杰 刘昌胜
• 机 构: Key Laboratory for Ultrafine Materials of Ministry of Education and Shanghai Key Laboratory of Advan
• 出 处: Journal of Wuhan University of Technology(Materials Science)
• 发表日期: 2016年01期
• 关键词: blends toughness rheological blending rheology lactic biomedical polyurethane bl

A polymer blends containing thermoplastic polyurethane(TPU) and poly(lactic acid)(PLA) as a biomedical material were prepared by a process of modifying thermally induced phase separation(MTIPS) and melt blending.The influences of composition,shear frequency,and temperature on the rheological behaviors of the blends were investigated by small amplitude oscillatory shear rheology.The results revealed that the addition of TPU into PLA significantly decreased the non-Newtonian index of the blends,and increased the sensitivity of the blends on shear rate,suggesting that optimization of the shear rate and temperature could improve the flowability of the blend melts in the extrusion process.In addition,the results of SEM images revealed that TPU distributed well into PLA matrix and showed good compatibility between the TPU and PLA,which made the blends with good toughness.The primary cytocompatibility of the blends was evaluated using C2C12 cells.The results suggested that the TPU/PLA blends did not affect cell growth,showing no cytotoxicity.In short,the TPU/PLA blends with excellent toughness had potential application as biomedical devices.

A polymer blends containing thermoplastic polyurethane (TPU) and poly (lactic acid) (PLA) as a biomedical material were prepared by a process of modifying thermally induced phase separation (MTIPS) and melt blending.The influences of composition, shear frequency, and temperature on the rheological behaviors of the blends were investigated by small amplitude oscillatory shear rheology. The results revealed that the addition of TPU into PLA significantly decreased the non-Newtonian index of the blends, and the the sensitivity of the blends on shear rate, suggesting that optimization of the shear rate and temperature could improve the flowability of the blend melts in the extrusion process. In addition, the results of SEM images revealed that TPU distributed well into PLA matrix and showed good compatibility between the TPU and PLA, which made the blends with good toughness. The primary cytocompatibility of the blends was evaluated using C2C12 cells. The results suggested that the TPU / PLA blends did not affect cell growth, showing no cytotoxicity. In short, the TPU / PLA blends with excellent toughness had potential application as biomedical devices.