Expression of Human Factor Ⅸ cDNA in Mice by Implants of Genetically Modified Skin Fibroblasts From

• 作 者: 周洁民 戴一凡 邱信芳 侯国英 Yoshioka Akira
• 机 构: InstituteofGenetics,FudanUniversity,Shanghai200433,PRC,NaraMedicalCollege,Nara,Japan,PRC
• 出 处: 中国科学：化学英文版
• 发表日期: 1993年9期
• 关键词: gene therapy RETROVIRAL VECTOR factor Ⅸ EXPRESSION in vivo. gene therapy retrovi

Double-copy retroviral vector containing human factor Ⅸ cDNA driven by human cytomegalovirus enhancer-promoter was constructed. The vector was introduced into the amphotropic packaging cell line PA317. The recombinant virus produced in PA317 was used to t