Contribution of lysosomal cysteine proteases in cardiac and renal diseases

• 作 者: Damin Huang Yang-Long Li Xianw
• 机 构: DepartmentofCardiology,DepartmentofCardiology,DepartmentofCardiology,DepartmentofCardiology,Departme
• 出 处: 世界高血压杂志
• 发表日期: 2012年3期
• 关键词: CYSTEINE proteases CATHEPSINS CYSTATIN C EXTRACELLULAR matrix proteins CARDIOVAS
• 基金项目: Supported by Grants from the Japan Heart Foundation/Novartis Research Award on Molecular and Cellular Cardiology,No.26-007523(to Cheng X),and The Scientific Research Fund of the Chinese Ministry of Ed

Cardiac and renal diseases(CRDs)are characterized by extensive remodeling of the extracellular matrix(ECM)architecture of the cardiorenal system.Among the many extracellular proteolytic enzymes present in cardiorenal cells and involved in ECM remodeling,m