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本研究利用常规 HE 染色和免疫组织化学方法对10例卵巢畸胎瘤(单发性5例,癌变1例,合并其他部位肿瘤4例)中上皮和间叶组织的细胞有丝分裂出现频度,PCNA 细胞阳性率及组织凋亡相关抗原 BM-1的表达分别进行检测。结果表明,癌变例上皮细胞单相细胞增生明显活跃;合并其他肿瘤例上皮和间叶细胞增生均较单发例活跃;良性上皮细胞及癌变细胞均可见细胞凋亡抗原表达。提示对卵巢畸胎瘤细胞增生状态的观察有助于该肿瘤的预后及了解合并其他部位肿瘤的可能性。
In this study, we used routine HE staining and immunohistochemistry to detect the frequency of cell mitosis in epithelial and mesenchyme of 10 ovarian teratoma (5 cases of solitary, 1 case of carcinomatous, 4 cases of other tumor), PCNA The positive rate of cell and the expression of tissue-associated antigen BM-1 were detected respectively. The results showed that the monocytic cells in epithelial cells of cancerous patients were proliferated obviously. The proliferation of epithelial and mesenchymal cells in other tumor cases was more active than that in single cases. The expression of apoptotic antigen was seen in benign epithelial cells and cancerous cells. Prompted observation of ovarian teratoma cell proliferation contribute to the prognosis of the tumor and understand the possibility of other parts of the tumor.