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过去30余年中的流行病学、动物实验、病理解剖的大量前瞻性与回顾性研究,均肯定了血浆胆固醇(CH)升高与动脉粥样硬化的伴随关系。随着对脂质在血浆脂蛋白(LP)的转运,分子生物学、细胞生物学、遗传学及流行病学研究的日益深入,近年焦点从血浆总胆固醇(TCH)移向LP的特殊组分,并揭示低密度脂蛋白-胆固醇(LDL-CH)为特别有害的成分,而高密度脂蛋白-胆固醇(HDL-CH)与冠心病(coronary heart disease,CHD)呈负相关。在临床上,由于CH测定方法简单易行;大量研究证明TCH对不同种族65岁以下人群,仍为
A large number of prospective and retrospective epidemiological, animal studies, and pathological dissections over the past 30 years have affirmed the association between elevated plasma cholesterol (CH) and atherosclerosis. With the development of lipid transport in plasma lipoprotein (LP), molecular biology, cell biology, genetics and epidemiology, the recent focus has shifted from plasma total cholesterol (TCH) to LP-specific components , And revealed that LDL-CH was a particularly harmful component, whereas HDL-CH was negatively correlated with coronary heart disease (CHD). Clinically, due to the CH assay is simple and easy; a large number of studies have shown that TCH of different ethnic groups under the age of 65, still