论文部分内容阅读
目的 :了解柳氮磺吡啶 (SAPA)与甲氨喋呤 (MTX)联合用药对强直性脊柱炎 (AS)的临床疗效。方法 :MTX15～ 2 0 mg1次 /周。SAPA1g2次 /日。连续服药 8个月 ,随访 3～ 12个月 ,疗程结束后判定疗效 ,同时记录和观察药物毒副反应 ,结果 :37例 AS患者有 2 5例临床缓解占 6 8% ,显效 9例占 2 4% ,有效 3例占 8% ,同时还观察到病情发作期、病程短、年龄小以及骶髂受累级越小 ,临床疗效越好 ,结论 :MTX+ SAPA联合用药对 AS有效 ,早期诊断 ,早期治疗有利于改善预后。用药疗程短、易复发 ,建议联合用药 ,病情控制后 ,改用单一药物维持 ,以使病情维持临床缓解状态。
Objective: To investigate the clinical efficacy of sulfasalazine (SAPA) and methotrexate (MTX) in the treatment of ankylosing spondylitis (AS). Methods: MTX15 ~ 20mg1 times / week. SAPA1g2 times / day. Continuous medication for 8 months, followed up for 3 to 12 months, after the end of treatment to determine the efficacy, while recording and observation of drug toxicity, results: 37 cases of AS patients, 25 cases of clinical remission accounted for 68%, markedly effective 9 cases accounted for 2 4%, effective 3 cases accounted for 8%, while also observed the onset of the disease, short course, small age and sacroiliac involvement level, the better the clinical efficacy, Conclusion: MTX + SAPA combination therapy effective on AS, early diagnosis, early Treatment is good for improving prognosis. Medication course is short, easy to relapse, it is recommended that the combination of medication, disease control, use a single drug to maintain, so that the disease maintains clinical remission status.