论文部分内容阅读
目的制备多奈哌齐乙醇脂质体,进一步优化有效药物的经皮转运。方法采用注入法制备多奈哌齐乙醇脂质体;通过形态,粒径分布和包封率对乙醇脂质体进行了初步表征,运用Franz扩散池和共聚焦激光扫描电镜考察乙醇脂质体的经皮转运情况。结果多奈哌齐乙醇脂质体(乙醇含量45%)包封率明显高于多奈哌齐脂质体;多奈哌齐乙醇脂质体透皮量分别为脂质体及乙醇溶液的3倍和1.6倍。结论乙醇脂质体可有效携带药物进入皮肤深层。
Objective To prepare donepezil ethanol liposomes to further optimize the transdermal delivery of effective drugs. Methods The donepezil ethanol liposomes were prepared by injection method. The ethanol liposomes were characterized by morphology, particle size distribution and entrapment efficiency. The percutaneous transport of ethanol liposomes was investigated by Franz diffusion cells and confocal laser scanning electron microscopy Happening. Results The entrapment efficiency of donepezil ethanol liposomes (ethanol content 45%) was significantly higher than that of donepezil liposomes. The drug delivery of donepezil ethanol liposomes was 3 times and 1.6 times that of liposomes and ethanol solution, respectively. Conclusion Ethanol liposomes can effectively carry the drug into the deep skin.