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目的了解温州地区妇科门诊女性生殖道人乳头状瘤病毒(HPV)感染状况,为宫颈癌的防治提供理论依据。方法采用导流杂交分型技术对2007年10月-2009年10月在妇科门诊就诊的1462例妇女进行生殖道21种HPV亚型感染检测。结果 1462例中HPV感染368例,总感染率为25.2%,高危型感染占16.2%,低危型占9.0%;21种亚型中除HPV44外,其他亚型均有检出,感染率最高的亚型是HPV16(6.7%),高危型中除HPV16外,HPV52、58、18和68型感染较多见;低危型以HPV6、11为主;HPV感染高峰年龄段在26～35岁(32.5%);不同年龄段、不同生殖道疾病患者HPV感染检出率差异均有统计学意义(P<0.01)。结论门诊高危人群HPV总感染率为25.2%,以高危型为主;高危型HPV感染与宫颈病变关系密切,因此,对门诊妇女有必要进行HPV感染筛查,对有高危型HPV感染人群,应定期随访和相应治疗,以降低宫颈癌的发病风险。
Objective To understand the infection status of human reproductive tract human papillomavirus (HPV) in gynecology clinic in Wenzhou area and to provide a theoretical basis for the prevention and treatment of cervical cancer. Methods A total of 1462 reproductive tract HPV subtypes were detected in 1462 women who were treated in the gynecology outpatient department from October 2007 to October 2009 by using the flow-through hybridization technique. Results Among the 1462 cases, 368 were HPV-infected, with a total infection rate of 25.2%, high-risk infection accounting for 16.2% and low-risk infection accounting for 9.0%. Among the 21 subtypes except HPV44, the other subtypes were detected with the highest infection rates Of the subtypes were HPV16 (6.7%). In addition to HPV16 in high-risk type, HPV types 52, 58, 18 and 68 were more common. In low-risk type, HPV6 and 11 were predominant. HPV infection peak age ranged from 26 to 35 years (32.5%). There was significant difference in the detection rate of HPV among different age groups and genital tract diseases (P <0.01). Conclusions High prevalence of HPV infection in outpatients is 25.2%, mainly in high-risk type. High-risk HPV infection is closely related to cervical lesions. Therefore, it is necessary to carry out screening of HPV in outpatients with high risk HPV infection. Regular follow-up and the corresponding treatment to reduce the incidence of cervical cancer risk.