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目的:探讨联合应用脑活素(Cerebrolysin)、1,6-二磷酸果糖(FDP)与胞二磷胆碱(CDPC)对中、重度新生儿缺氧缺血性脑病(HIE)的疗效。方法:将120例中、重度新生儿HIE患儿随机分为两组,脑活素(Cerebrolysin)、1,6-二磷酸果糖(FDP)与胞二磷胆碱(CDPC)联合应用作为观察组,单独应用CDPC作为对照组,各60例。通过对临床症状、体征消失时间作为疗效评价指标。结果:治疗组在治疗有效率、显效率与对照组比较差异有显著性(P<0.05)。结论:脑活素(Cerebrolysin)、1,6-二磷酸果糖(FDP)与胞二磷胆碱(CDPC)联合应用治疗HIE较传统单一用药临床疗效更满意。
Objective: To investigate the therapeutic effects of Cerebrolysin, FDP and CDPC on moderate and severe neonatal hypoxic-ischemic encephalopathy (HIE). Methods: One hundred and twenty cases of moderate and severe neonates with HIE were randomly divided into two groups. Cerebrolysin, fructose-1,6-diphosphate (FDP) and citicoline (CDPC) were used as observation group , CDPC alone as a control group, each 60 cases. Through clinical symptoms, signs of disappearance of time as a curative effect evaluation index. Results: There was significant difference between the treatment group and the control group (P <0.05). Conclusion: Cerebrolysin, FDP and CDPC are more satisfactory than the traditional single therapy in the treatment of HIE.