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分析稳定性心绞痛（SAP）、不稳定性心绞痛（UAP）和急性心肌梗塞（AMI）患者的冠状动脉（冠脉）病变、血浆内皮素（ET）和心钠素（ANP）水平的变化，以探讨冠卧病变、ET和ANP在急性冠脉综合征发病中的作用。结果表明：AMI和UAP的单支血管病变占绝大多数（88.2％和60％），而SAP的2支和3支血管病变更常见（占81．3％），SAP的平均血管病变数、狭窄和闭塞数以及病变范围评分均显著高于UAP和AMI组（P＜0．05），而UAP和AMI两组血管病变相似。AMI和UAP的血浆ET和ANP显著高于SAP组。提示冠脉病变程度和范围无法预测能否发生急性冠脉综合征，ET和ANP可能在其发病机理中起重要作用。
To analyze the changes of coronary artery (coronary artery), plasma endothelin (ET) and atrial natriuretic peptide (ANP) in patients with stable angina pectoris (SAP), unstable angina pectoris (UAP) and acute myocardial infarction To investigate the role of coronary disease, ET and ANP in the pathogenesis of acute coronary syndrome. The results showed that the single vessel lesions of AMI and UAP accounted for the vast majority (88.2% and 60%), while the second and third vessel lesions of SAP were more common (81.3%), the mean number of SAP lesions, The number of stenosis and occlusion, as well as the extent of lesion, were significantly higher than those in UAP and AMI groups (P <0.05), while those in UAP and AMI groups were similar. Plasma ET and ANP in AMI and UAP were significantly higher than those in SAP group. Suggesting that the extent and extent of coronary lesions can not predict the occurrence of acute coronary syndrome, ET and ANP may play an important role in its pathogenesis.