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目的 探讨新生儿缺氧缺血性脑病(HIE)的酸碱紊乱发生情况和血液阴离子间隙(AG)状态。方法 对65例HIE患儿进行血气、血清电解质及AG测定,应用预计代偿公式判断酸碱紊乱类型。结果 高AG 73.8％(48/65),正常AG 23.1％(15/65),低AG 3.1％(2/65)。单纯酸碱紊乱32.3％(21/65),双重酸碱紊乱56.9％(37/65),三重酸碱紊乱(TABD)6.2％(4/65),正常4.6％(3/65)。HIE患儿血液酸碱紊乱呈高AG状态;AG值的高低、高AG发生率及酸碱紊乱类型的分布与HIE临床分度无关(P>0.05)。结论 HIE酸碱紊乱呈高AG状态,代谢性酸中毒和呼吸性碱中毒是2种最基本的酸碱紊乱。
Objective To investigate the occurrence of acid-base disorders and plasma anions (AG) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Blood gases, serum electrolytes and AG were measured in 65 children with HIE. The predictive compensation formula was used to determine the type of acid-base disorders. Results High AG 73.8% (48/65), normal AG 23.1% (15/65), low AG 3.1% (2/65). The simple acid-base disorders were 32.3% (21/65), double acid-base disorders 56.9% (37/65), triple acid-base disorders (TABD) 6.2% (4/65) and normal 4.6% (3/65). HIE children with high blood acid-base disorder AG status; AG value, the incidence of high AG and the distribution of acid-base disorders type and HIE clinical index has nothing to do (P> 0.05). Conclusions HIE acid-base disorder is a high AG state, and metabolic acidosis and respiratory alkalosis are the two most basic acid-base disorders.