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目的探讨肾癌中转化生长因子β１（ＴＧＦβ１）及其Ｉ、Ｉ型受体（ＴＧＦβＲＩ、ＴＧＦβＲＩ）表达及其意义。方法采用免疫组化技术（ＳＰ法）对４６例肾癌，１１例正常肾组织ＴＧＦβ１、ＴＧＦβＲＩ、ＲＩ进行检测，结合临床资料进行分析。结果肾癌组ＴＧＦβ１表达量较正常肾组高（Ｐ＜０．０５）；ＴＧＦβＲＩ在肾癌组及正常肾组均表达；ＴＧＦβＲＩ在肾癌中阳性率较正常肾阳性率低（Ｐ＜０．０１），ＴＧＦβＲＩ在高分期，高分级肾癌中表达阳性率较低分期、低分级肾癌低（Ｐ＜０．０５）；ＴＧＦβ１表达量低及ＴＧＦβＲＩ表达阴性肾癌者预后差。结论ＴＧＦβ１对肾癌是一种重要负性调节因子，可抑制肾癌进展，ＴＧＦβＲＩ缺失使ＴＧＦβ系统完整性受到破坏，ＴＧＦβ１失去负性调节作用。ＴＧＦβ１及ＴＧＦβＲＩ表达可做为判断肾癌预后的指标之一
Objective To investigate the expression of transforming growth factor β1 (TGFβ1) and its type I and type I receptors (TGFβRI, TGFβRI) in renal cell carcinoma and its significance. Methods The expressions of TGFβ1, TGFβRⅠ, RI in 46 cases of renal cell carcinoma and 11 cases of normal renal tissue were detected by immunohistochemistry (SP method). The clinical data were analyzed. Results The expression of TGFβ1 in renal cell carcinoma group was significantly higher than that in normal renal cell group (P <0.05). TGFβR expression was detected in both renal cell carcinoma and normal kidney cells. The positive rate of TGFβR was higher than that in normal renal cell The positive rate of TGFβR was lower than that of low grade renal cell carcinoma (P <0.01), while the expression of TGFβR was lower (P <0.05) Prognosis of TGFβ R-I-negative renal cell carcinoma is poor. Conclusion TGFβ1 is an important negative regulator of renal cell carcinoma, which can inhibit the progression of renal cell carcinoma. The loss of TGFβRI results in the destruction of the integrity of TGFβ system and the loss of negative regulation of TGFβ1. TGFβ1 and TGFβ R expression can be used as one of the indicators to determine the prognosis of renal cell carcinoma