论文部分内容阅读
许多研究者评价了各个种属包括人类持续长时间应用大剂量黄体生成素释放激素(LHRH)激动剂,如〔D-Trp~6〕LHRH,可引起抗生育作用。这种现象是垂体性腺轴向下调节的特征,并表明垂体分泌LH和FSH降低。另有报告提示,当单次应用高效的LHRH类似物颉颃剂和激动剂后引起垂体性腺轴抑制,是因为两者作用于腺垂体同一受体,通过竞争性抑制作用,导致促性腺激素和性腺类固醇的释放即刻受到抑制,但也有报告认为LHRH激动剂和颉颃剂对一般小鼠无抗生育作用。1983年Wang等研究表明小鼠的Leydig细胞无LHRH受体。因实验动物种属不同,持续长时间应用LHRH高效颉颃剂,对睾丸组织的敏感性亦不同。本文研究为探索两个新的高效LHRH颉颃剂(SB-30,
Many researchers have evaluated the long-term use of high-dose LHRH agonists such as [D-Trp-6] LHRH by various species, including humans, for a long time to cause anti-fertility effects. This phenomenon is characterized by axial down regulation of the pituitary gland and indicates a decrease in LH and FSH secretion by the pituitary gland. Another report suggests that when a single application of highly effective LHRH analog antagonists and agonists cause pituitary gland axis inhibition, because the two act on the same pituitary gland receptor, through competitive inhibition, leading to gonadal hormones and gonads Steroid release was immediately suppressed, but there are also reports that LHRH agonists and antagonists have no anti-fertility effects on normal mice. In 1983 Wang and other studies have shown that mice without Leydig cells LHRH receptor. Due to the different experimental animal species, sustained long-term application of LHRH antagonist, testis sensitivity is also different. This study is to explore two new highly effective LHRH antagonists (SB-30,