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目的 :①观察研究纳洛酮在心肺脑复苏中的作用机理及实际疗效 ;②研究心搏骤停患者血中 β -内啡肽 (以下简称 β -EP)与正常人的差异。 方法 :①随机划分急诊和住院抢救的心搏骤停患者为纳洛酮复苏组与常规复苏组两组。前者以常规复苏为基础 ,再给予纳洛酮2 0mg加生理盐水 2 0ml静注 ,并可间隔 30min多次重复使用。②对常规复苏组和对照组 2 0例健康体检者均抽静脉血 5ml入专用抗凝管离心取血清存放于冰箱、集中一次测定 β -EP。 结果 :纳洛酮组复苏成功率 42 9% ,常规组复苏成功率 14 3% ,纳洛酮组复苏成功率显著高于常规组(P <0 0 5 )。心搏骤停患者血中 β -EP含量较正常人明显增高。 结论 :纳洛酮作为阿片受体纯拮抗剂 ,从多个环节中促进了心肺脑诸器官复苏 ,故临床应用纳洛酮可明显提高心肺脑复苏成功率
PURPOSE: To observe and study the mechanism of naloxone in cardiopulmonary resuscitation and the actual therapeutic effect. To study the difference between β - endorphin (β - EP) and normal subjects in patients with cardiac arrest. Methods: ① Randomly divided emergency treatment and hospitalized patients with cardiac arrest for naloxone resuscitation group and conventional resuscitation group. The former is based on conventional recovery, and then given naloxone 20mg intravenous infusion of 20ml intravenous injection, and 30min interval repeated use. ② routine recovery group and control group 20 healthy subjects were drawn venous blood 5ml into the dedicated anticoagulant tube centrifuged serum, stored in a refrigerator, focused on a determination of β -EP. Results: The successful rate of naloxone group was 42 9%, and the success rate of routine group was 14 3%. The success rate of naloxone group was significantly higher than that of conventional group (P 0.05). Β-EP levels in patients with cardiac arrest were significantly higher than normal. Conclusion: Naloxone, as a pure antagonist of opioid receptor, promotes the recovery of cardiopulmonary and brain organs from multiple aspects. Therefore, the clinical application of naloxone can significantly improve the success rate of cardiopulmonary resuscitation