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目的了解老年脑血管病患者发病早期血液中C反应蛋白(CRP)含量高低与病情程度及预后的关系,评价步长脑心通对缺血性脑梗死CRP的干预作用。方法126例老年急性脑血管病采用免疫透射比浊法测定血清CRP浓度,并分析病情程度及预后的关系。对其中68例缺血性脑梗死采用随机分组分为对照组和治疗组,治疗组应用步长脑心通4片3次/d治疗4周后复查CRP,其它治疗2组相同,观察2组4周时CRP的变化。结果老年ACVD的CRP明显高于对照组(健康体检老年人)差异有统计学意义(P<0.01)。就诊时CRP浓度与神经功能缺损程度评分,二者呈正相关(r=0.695,P<0.01)。神经功能缺损程度评分减分率与入院时CRP浓度,二者呈负相关(r=-0.501,P<0.05)。死亡病例CRP值明显高于存活病例CRP值(P<0.01)。对68缺血性脑梗死中部分应用步长脑心通治疗4周(n=38)的CRP值的下降比对照组(n=30)更为明显(P<0.05)。结论CRP测定对老年急性脑血管病有重要的意义,并对病情严重程度和预后的判断有较大的价值,简便价廉,值得临床的推广。步长脑心通有望干预老年缺血性脑梗死CRP的产生。
Objective To investigate the relationship between the level of C-reactive protein (CRP) and the severity and prognosis in the elderly patients with cerebrovascular disease and to evaluate the intervention effect of Stephenaxin on CRP in ischemic cerebral infarction. Methods The serum CRP levels were measured by immunoturbidimetric method in 126 elderly patients with acute cerebrovascular disease. The relationship between the severity and prognosis was analyzed. The 68 cases of ischemic cerebral infarction were randomly divided into control group and treatment group. The treatment group was treated with 4 steps of Naoxintong 4 times a day for 4 weeks, then the CRP was examined. The other two groups were the same. The observation group 2 Changes in CRP at 4 weeks. Results The CRP of elderly patients with ACVD was significantly higher than that of the control group (healthy elderly) (P <0.01). There was a positive correlation between CRP concentration and neurological deficit score (r = 0.695, P <0.01). The score of neurological deficit score was negatively correlated with the concentration of CRP on admission (r = -0.501, P <0.05). The CRP value of death cases was significantly higher than that of survivors (P <0.01). The reduction of CRP value in the ischemic cerebral infarction with partial application of Naoxintong for 4 weeks (n = 38) was more obvious than that in the control group (n = 30) (P <0.05). Conclusion The determination of CRP is of great significance to elderly patients with acute cerebrovascular disease. It is of great value in judging the severity and prognosis of the disease, which is simple, inexpensive and worthy of clinical promotion. Step mind is expected to intervene in senile ischemic cerebral infarction CRP production.