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作者报道1例成人特发性慢性纯红细胞再生障碍性贫血(PRCA),经一个疗程抗淋巴细胞球蛋白治疗取得持续的临床和血液学缓解。患者为25岁已婚女性,因进行性乏力2月入院,曾服用乙酰水杨酸盐治疗头痛4个月。无其他疾病史。除贫血体征外无异常发现。实验室检查:血红蛋白(Hb)4.3g/dl,平均红细胞体积95.2fl,平均红细胞血红蛋白量33pg,白细胞总数2.1×10~9/L,中性粒细胞47%,淋巴细胞45%,两者形态无异常,网织红细胞O。血沉3mm/小时。血小板110×10~9/L。胸片和CT检查未见胸腺瘤,胸、腹部无异常发现。骨髓涂片及活检除缺乏红系前体细胞外未见异常。骨髓培养粒单系集落形成单位(CFU-GM)4个集落,33个簇(正常20-60个集落,60-140个簇)。外周血和骨髓
The authors report 1 adult idiopathic chronic pure aplastic anemia (PRCA) achieving sustained clinical and hematologic response after a course of anti-lymphocyte globulin therapy. The patient was a 25-year-old married woman who had been treated with acetylsalicylate for 4 months because of progressive fatigue in February. No other disease history. No abnormal findings except anemia. Laboratory tests: hemoglobin (Hb) 4.3g / dl, the average volume of red blood cells 95.2fl, the average amount of red blood cells hemoglobin 33pg, the total number of leukocytes 2.1 × 10 ~ 9 / L, 47% of neutrophils, lymphocytes 45% No abnormalities, reticulocytes. ESR 3mm / hour. Platelets 110 × 10 ~ 9 / L. Thoracic and CT examination showed no thymoma, chest, abdomen no abnormal findings. Bone marrow smear and biopsy in addition to the absence of erythroid precursor cells without exception. Four colonies of 33 CFU-GM colonies (normal 20-60 colonies, 60-140 colonies) were cultured in bone marrow. Peripheral blood and bone marrow