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目的:探讨Caspase-3和Bcl-2蛋白在膀胱移行细胞癌中的表达及其与病理分级和临床分期的关系。方法:采用免疫组化SABC法并结合图像分析方法检测32例膀胱移行细胞癌和10例膀胱正常组织中Caspase-3和Bcl-2蛋白的表达。结果:Caspase-3和Bcl-2两种蛋白在膀胱移行细胞癌中的表达与正常膀胱组织之间都有显著性差异(P<0.05)。Caspase-3与病理分级和临床分期均无显著性差异(P>0.05),Bcl-2与病理分级和临床分期均无显著性差异(P>0.05),Caspase-3和Bcl-2两者之间呈负相关(rs=-0.358,P<0.05)。结论:在膀胱癌组织中Caspase-3的表达降低和Bcl-2的表达升高可能与膀胱癌的发生发展有关。
Objective: To investigate the expression of Caspase-3 and Bcl-2 in bladder transitional cell carcinoma and its relationship with pathological grade and clinical stage. Methods: The expressions of Caspase-3 and Bcl-2 in 32 cases of bladder transitional cell carcinoma and 10 cases of normal bladder tissue were detected by immunohistochemical SABC method and image analysis method. Results: The expressions of Caspase-3 and Bcl-2 in bladder transitional cell carcinoma were significantly different from those in normal bladder tissue (P <0.05). Caspase-3 had no significant difference with pathological grade and clinical stage (P> 0.05), Bcl-2 had no significant difference with pathological grade and clinical stage (P> 0.05), Caspase-3 and Bcl- (Rs = -0.358, P <0.05). Conclusion: The decrease of Caspase-3 expression and the increase of Bcl-2 expression in bladder cancer may be related to the occurrence and development of bladder cancer.